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Prostaglandin E2 (PGE2), previously mentioned, synthesized via COX-2 and mPGES-1, is also elevated during seizures and inhibits neuronal membrane pumps thereby triggering neuronal hyperexcitability

This combination targets the brains reward and appetite systems: Bupropion component: Acts on dopamine and norepinephrine pathways in the brain Originally developed as an antidepressant (Wellbutrin) and smoking cessation aid (Zyban) Reduces appetite through hypothalamic effects May increase energy expenditure modestly Affects reward pathways that influence food-seeking behavior Naltrexone component: Blocks opioid receptors in the brain Originally used for alcohol and opioid addiction treatment Reduces the rewarding aspects of eating May blunt the pleasure response to highly palatable foods Enhances bupropions appetite effects when combined Combined effect: The medications work synergistically